Progressive dilation of the aortic root is considered one of the most serious manifestations of Marfan syndrome. The antihypertensive losartan is one of the two medications recommended by current guidelines attenuate the progression of this aortic enlargement, but which medication works best is still controversial. A new report in The American Journal of Pathology confirms losartan’s efficacy but finds that the underlying mechanism of action is different than previously thought, opening up new possibilities for improvements in Marfan syndrome management.

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