Why don’t we ever develop immunity against the common cold? The incredible variability of coronaviruses is better understood with this study about the ways in which coronaviruses adapt and evolve, becoming ever more effective at infecting hosts without being defeated by the immune system. The receptor binding domain (RBD) of coronavirus S-protein displays three highly variable extended loops that modulate the affinity to both the receptor on a target cell and the neutralizing antibodies.

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