The brain consists of neurons and glial cells. Recent research uncovers the importance of glial cells; their developmental abnormality causes various diseases and aberrant cerebral cortex development. Herein, C38 gene knocking-out is shown to cause aberrant development of glial cells, especially, those called astrocytes and oligodendrocytes. CD38 gene is known to be involved in the cerebral cortex development. The present study suggests the importance of glial cells for the cerebral cortex development.

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